Metabolome analysis by CE-MS.

High-sensitive protein analysis by FESI-CE-MALDI-MS.

Capillary zone electrophoresis (CZE) and matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) are two techniques highly suitable for the separation and detection of intact proteins. Herein, based on the use of a recently introduced iontophoretic fraction collection interface for the coupling of CE and MALDI-MS, the potential of the combination of both techniques for the anal...

Determination of Benzodiazepines in Urine by CE-MS/MS

Using capillary electrophoresis combined with tandem mass spectrometry, we have developed a method to simultaneously detect lorazepam, clonazepam, temazepam, oxazepam, diazepam, and nitrazepam in urine. The urine samples were submitted to a modified QuEChERS extraction procedure, followed by electrophoretic separation in 0.1 M formic acid electrolyte (pH 2.4) using a polyvinyl alcohol (PVA)-coa...

Analysis of Aromatic Amines Derived From Banned Azo Dyes in Textiles by CE-MS/MS

Determination of 3,4-MDMA in Ecstasy Tablets by CE-MS/MS

A capillary electrophoresis tandem mass spectrometry method (CE-MS/MS) was developed for the determination of 3,4-methylenedioxymethamphetamine (3,4-MDMA) in Ecstasy tablets. In this study, Ecstasy tablets seized in Rio de Janeiro, Brazil, were homogenized and diluted before electrophoretic separation in 0.1 M formic acid electrolyte (pH 2.4) using a polyvinyl alcohol (PVA)-coated capillary. Se...

Determination of Perfluorinated Carboxylic Acids in Human Plasma by CE-MS/MS

This application note describes a sensitive and reliable method for the determination of perfluorinated carboxylic acids (PFCAs) in human plasma. PFCAs were extracted from a plasma sample using an optimized QuEChERS protocol, followed by CE-MS/MS analysis. The optimal separation of investigated PFCAs was achieved in less than 9 minutes using 25 mM ammonium acetate buffer and 1 % isopropanol (pH...